UNIVERSAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH

Thiolated polymers: As bio inspired polymers

Jinendra Jain — 2023-06-30

Thiomers are polymers that have had their backbones changed by adding thiol moieties by substitution reactions or direct oxidation reactions which provides them mucoadhesive characteristics and other additional qualities. Thiomers can be complexed with drugs that are less soluble and permeable to boost their absorption via the mucosal membranes by increasing contact time and prolonging their stay in the body due to mucoadhesion. Therefore, immobilisation of the thiol group improves the modified polymer's mucoadhesive characteristics by 2-140 folds. Different methods are used to characterise and stabilise the produced thiomers. Additionally, thiomers provide the body with a regulated release of the active medicinal substances. Chitosan, polyacrylic acid, sodium alginate, sodium carboxy methyl cellulose, guar gum, and other polymers can all be altered by thiolation. Drugs having low therapeutic compatibility are difficult to deliver with thiomeric formulations. Thiomer-containing micro- and nanopreparations can be made using a variety of methods, including covalent crosslinking, in situ gelation, radical emulsion polymerization, and emulsification. Thiomers are a promising pharmaceutical excipient with a wide range of applications nowadays in the testing phase of pharmaceutical technology.

Review on oral suspensions for paediatric patient

Tanmoy Bhattacharjee — 2023-06-30

Majority of the conventional dosage form are unacceptable for paediatric patients, since have different developmental needs and dosing requirements than other segments of the population. The prerequisites for a quantifiable dosage form to provide depending on bodyweight and also flavour profile are two of the obstacles specific to paediatric oral formulations, making them quite scientifically difficult to design. The biopharmaceutical and physicochemical properties of the active pharmaceutical ingredient such as physical or chemical stability, solubility are determine which formulation is suitable. More regulatory incentives have recently led to an increase in the development of paediatric formulations. The aim of this review is to provide the information about the recent approaches to oral suspensions, its various limitations and advantages, the rationale on formulation of oral suspension, different excipient used in formulation, some marketed formulations.

A review on herbal lipstick from different natural colouring pigment

Nishan Hazra — 2023-06-30

Cosmetics are still in high demand now because they have integrated themselves into our culture and fashion. Lip glosses are most frequently utilized to improve lip appeal, and they also play a significant role in maintaining health and happiness. Synthetic colorants have been discovered to be naturally carcinogenic and may induce allergy reactions. The need for cosmetics has been enormous since antiquity. For lips to look more beautiful, lipstick formulas are utilized. A cosmetic item called lipstick gives the lips color, texture, and protection by combining pigments, oils, waxes, and emollients. All- natural and safe to use, the ingredient in natural lipstick. Natural nutrients that maintain healthy lips are also present.

Use of synthetic lipstick colors on a regular basis has the potential to have major negative effects, including cancer and skin rashes. The negative impact can be minimized by utilizing natural color extracts from various natural sources. The formulation, extraction of natural colorants, assessment of lipstick, and flaws in lipstick are the primary topics of this review

Anti-aging activity of various topical nano herbal formulations

Saurav Kr. Sarma — 2023-06-30

We utilised a variety of medicinal plants because, as we all know, they are excellent providers of many vitamins and minerals that are used to treat a variety of ailments, including ageing and other disorders. The majority of plants include a combination of elements that work together synergistically to increase a drug's ability to treat problems associated with ageing. Natural herbal plant formulations were created by combining various plant extracts or ingredients in varying proportions to create cream, oil, gel, and lotion. Although helpful in the treatment of ageing issues and a number of ailments, it also has some restrictions when used topically. Some of these restrictions include the potential for localised skin irritation, poor drug permeability through the skin, the difficulty of absorbing drugs with larger particle size and higher molecular weight through the skin, the possibility of toxic reactions following application, or the possibility that drugs may be denatured by the enzymes found in the epidermis. With the advancement of innovative technologies like nanotechnology, we can now get beyond the drawbacks of conventional topical formulations. The typical properties of products created with the aid of nanotechnologies include biocompatibility, biodegradability, a longer duration of action, the ability to perform numerous functions, the ability to modify drug release, potential targeting, and reduced toxicity, among many others. The purpose of the present review is to study different medicinal plants having anti-ageing activity. The review mainly focusses on various nanotechnology based herbal formulations which can be use to enhance the effectiveness in anti-ageing activity. However, nanotechnology has established that it can provide tools to overcome the problem associated with herbal medicine

A Review on Microsponage Drug Delivery System

Sima Mallick — 2023-06-30

The delivery method for microsponges is a highly cross-linked, porous, polymeric microsphere system that can entrap and release substances into the skin over time. It is a novel obtainment which offering many benefits for drug administration. The performance of medications delivered topically, parenterally, and orally is improved by the use of microsponges drug delivery systems. Microsponges with particle sizes between 10 and 20 microns in diameter can entrap a wide range of different components and release them at predetermined rates. Additionally, microsponges provide regulated medication release at a specific place while also allowing the drug to circulate throughout the entire body. Microsponges effects might last up to 12 hours. Microsponges are reliant on the physiochemical characteristics of the medication. MDS has made by various method utilization emulsion system or by suspension polymerization between a liquid-liquid system. Microsponges can be used in formulations including creams, powders, gels, and lotions to entrap different types of drugs. The formulations of microsponge are stable from pH 1 to 11; 130°c. Therefore, the development of microsponge drug delivery systems has great potential and is a rapidly developing topic that will require further future research.