UNIVERSAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH

Pharmacological activities of anti-hypertensive drug delivery through a transdermal patch – a brief review

Arif Mahammad, Sumit Sinha Mahapatra, Sudip Das, Sanjib Bahadur — Sat, 31 Dec 2022 00:00:00 +0530

One of the methods falling under the category of controlled drug delivery is the transdermal drug delivery system (TDDS), which is designed to distribute the medicine via the skin at a predefined and regulated pace. Hypertension is one of the largest death-causing diseases in mankind. Since it is a chronic disease, it required continuous treatment. The disadvantages of antihypertensive drugs such as more frequent administration, extensive first-pass metabolism and variable bioavailability, making them an ideal candidate for transdermal drug delivery systems. This article is dedicated to reviewing antihypertensive transdermal patches from the perspective of enhancing bioavailability and improving patient compliance. The various antihypertensive drugs considered in the review include timolol maleate, nicardipine hydrochloride, captopril, verapamil hydrochloride, nifedipine, propranolol hydrochloride, diltiazem hydrochloride, amlodipine besilate and carvedilol. Clonidine was the first antihypertensive drug developed in the transdermal form. Recently, various antihypertensive transdermal patches are available in the pharmaceutical market. Most of the reported methods in the literature employed the solvent evaporation method or solvent casting method for the preparation of transdermal patches. Depending on the release required over some time, the concentrations of polymer, plasticizer and penetrant were varied.

An alternate method for nasal medicine delivery is in-situ gel

Sumit Sinha Mahapatra, Arif Mahammad, Sanjib Bahadur, Pragya Baghel — Sat, 31 Dec 2022 00:00:00 +0530

Nasal medication administration has been used for therapeutic and recreational purposes since the dawn of civilization. The importance of and interest in the systemic effects of medications taken orally has grown over the past few decades. Medications administered intra-nasally provide an intriguing option to the parenteral route, which can occasionally be uncomfortable. These might involve avoiding pre-systemic release in the digestive tract and eliminating the first-pass effect (GIT), necessitating the use of a tiny dose of a specific medicine. Lowering the dose will lessen the negative effects and, ultimately, lower the cost of the medication. The likelihood for intranasal medication delivery to overcome certain significant drawbacks is linked with the other stated routes making it the most exciting path for drug administration. This review covered how in situ gel became more popular than previous nasal administration forms.

Medicated chewing gum: as a new generation drug carrier/dosage form

Sat, 31 Dec 2022 00:00:00 +0530

The study and development of oral medication delivery systems has seen advancements in both medicine and technology in recent years. Due to greater patient compliance, not only in geriatric and paediatric patients but also in the general population, medicated chewing gum has attracted attention on a global scale throughout the year. This distribution mechanism for drugs since it is easy to use and works without water, self-medication. The invention of medicated chewing gums (MCGs) heralds a revolutionary new era in oral transportable medication. It is described as a solid single-dose formulation with a base of gum that must be effortlessly chewed for a set amount of time. It may also have more than one active component. Additionally, because the official Pharmacopoeias only suggest a small number of tests, there aren't many assessment parameters available

Comparative study of different binder concentration of aloe as natural binder in the preparation of paracetamol tablet

Sat, 31 Dec 2022 00:00:00 +0530

Natural binders like different starches, gums, mucilage dried fruits possess binding capacity and are much safer and economical than polymers like PVP. The aim of the work was to compare different concentration of Aloe vera mucilage as a binder for preparation of Paracetamol tablet. The results of the study revealed that 5% aloes mucilage concentration shows good drug release pattern for conventional oral tablets of Paracetamol. Thus, it can be concluded that 5% Aloe vera mucilage may be used as a binder in tablet formulation and possess a high potential for substitution for other more expensive binders.

Formulation of Metformin Hydrochloride tablet using fenugreek seed mucilage.

Sat, 31 Dec 2022 00:00:00 +0530

This research work aims to develop Metformin Hydrochloride tablet using fenugreek seed mucilage. Fenugreek seed has antidiabetic activity. It also contains a major proportion of mucilage. The mucilage was extracted by soaking the powdered seed into water for 12-14 hours then, after filtration the filtrate was mixed with ethanol and the precipitated mucilage was dried and grounded into powder. The tablet utilizing the mucilage as excipient was prepared by wet granulation method. The tablets were subjected to various tests. The evaluatory parameters of tablets were found to be within the limits as per Indian Pharmacopoeia.