Thiolated polymers: As bio inspired polymers
Keywords:
Thiolated Polymers, Classification, Applications, MethodAbstract
Thiomers are polymers that have had their backbones changed by adding thiol moieties by substitution reactions or direct oxidation reactions which provides them mucoadhesive characteristics and other additional qualities. Thiomers can be complexed with drugs that are less soluble and permeable to boost their absorption via the mucosal membranes by increasing contact time and prolonging their stay in the body due to mucoadhesion. Therefore, immobilisation of the thiol group improves the modified polymer's mucoadhesive characteristics by 2-140 folds. Different methods are used to characterise and stabilise the produced thiomers. Additionally, thiomers provide the body with a regulated release of the active medicinal substances. Chitosan, polyacrylic acid, sodium alginate, sodium carboxy methyl cellulose, guar gum, and other polymers can all be altered by thiolation. Drugs having low therapeutic compatibility are difficult to deliver with thiomeric formulations. Thiomer-containing micro- and nanopreparations can be made using a variety of methods, including covalent crosslinking, in situ gelation, radical emulsion polymerization, and emulsification. Thiomers are a promising pharmaceutical excipient with a wide range of applications nowadays in the testing phase of pharmaceutical technology.
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