DERIVATIVE SPECTROPHOTOMETRIC METHOD WITH GREENNESS ASSESSMENT FOR THE SIMULTANEOUS DETERMINATION OF NAPROXEN AND DOMPERIDONE
DOI:
https://doi.org/10.61114/UJPSR.10.1.2026.39-44Keywords:
Naproxen, Domperidone, Zero-crossing point, first-order derivative, spectrophotometricAbstract
A simple and accurate first-order derivative UV method was developed for simultaneous estimation of Naproxen and Domperidone. The method resolves spectral overlap using 255 nm for Domperidone and 283.5 nm for Naproxen. Linearity was performed in the range of 5–100 µg/mL for Naproxen and 1–100 µg/mL for Domperidone, with correlation coefficients (R²) of 0.999 and 0.998, respectively. Precision studies shows low %RSD values (<1.5%), and recovery ranged from 97.91% to 102.39% for Naproxen and 99.33% to 101.25% for Domperidone, complying the method's accuracy and reproducibility. The limits of detection and quantification were found to be 1.09 and 3.30 µg/mL for Naproxen and 1.096 and 3.32 µg/mL for Domperidone. Greenness assessment was carried out using Analytical Eco-Scale (score: 80), Green analytical procedure index (68), Blue analytical grade index (67.5), and Analytical GREEness matric approach (0.48).The method is sensitive, reliable, and moderately green for routine analysis of Naproxen and Domperidone.
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