Analytical method development and validation of atenolol by using spectroscopic analytical grade solvent
DOI:
https://doi.org/10.61114/UJPSR.10.1.2026.20-25Keywords:
atenolol, uv spectroscopy, no cost solvent, method development, method validationAbstract
Cardio-vascular disorder is the most leading cause of death in world wide . India is also prone to cardiovascular disorder. To treat this disorder many drugs have been developed out of which atenolol is one of the important drug. Atenolol is beta blocker having 4-[2-hydroxy-3-[(1 methylethyl) amino] propoxy] benzene-acetamide nucleus in it’s structure. Atenolol binds to the beta receptor of heart and decreases blood pressure, ultimately treats cardiac disorder. There are different methods for estimation of atenolol conc. like HPLC, RP-HPLC, UP-HPLC, LC, GC, MS. But these techniques are more costly , complicated and required export technician. To avoid this difficulties the UV method came, which is simple, accurate, specific, more precise and cost effective. There are different UV methods for estimation of atenolol which requires the solvent that may be costly. We know our body contains 85-90% water. This research explains the analytical method development and validation using no cost solvent i.e in spectroscopic grade distilled water. Water is mostly present in our body & easily available outside and solubility of atenolol in spectroscopic grade distilled water is good. So we can use water as solvent to determine the atenolol by UV which shows good absorbance.
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