A Comprehensive Review on Cytotoxic Potential of Atropa acuminata
DOI:
https://doi.org/10.61114/UJPSR.10.1.2026.26-31Keywords:
Atropa acuminata, cytotoxicity, tropane alkaloids, atropine, alkaloid extraction, acid-base extraction, phytochemical analysis, MTT assay, anticancer potentialAbstract
Atropa acuminata it contains various bioactive compounds, like particularly tropane alkaloids, it contributes to its therapeutic properties. Different alkaloids found within this plant include; atropine, hyoscyamine, and scopolamine demonstrating sedative, anti-spasmodic, and antidote properties. The therapeutic effects of the plant are further enhanced by the other classes of phytochemicals the plant contains, including flavonoids, tannins, saponins, anthraquinones, and phytosterols. Because of the plant's extensive class of phytochemicals and long history of traditional use, scientific research has looked into a variety of impacts of the plant. The phytochemical components of plants have been the subject of extensive scientific research about their anticancer properties. Information for this study was acquired from many credible scholarly sources. All sources of information were employed to identify the technique in which atropine can be produced from dried leaf and root elements of the plant.The study also examined several extraction methods for pharmaceuticals, the effects of induced mutagenesis via sodium azide and ethyl methane sulphonate (EMS) on the yield of alkaloids, and the anticancer properties of plant extract through in vitro testing. Atropine was isolated via an acid-base extraction process followed by purification and chemical, chromatographic, and non-aqueous titration methods were used to identify and quantify the isolated compound. Using the MTT test, the cytotoxicity of the ethanol extract was evaluated on HEp-2 human epithelial carcinoma cell lines. The findings confirmed successful isolation and purity of atropine. The extract exhibited strong, dose-dependent cytotoxic action, suggesting intriguing anticancer potential, and mutagenesis showed promise in boosting alkaloid synthesis.
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