A Review on Microsponage Drug Delivery System
Keywords:
Microsponge, Controlled release, Topical formulation, Oral administrationAbstract
The delivery method for microsponges is a highly cross-linked, porous, polymeric microsphere system that can entrap and release substances into the skin over time. It is a novel obtainment which offering many benefits for drug administration. The performance of medications delivered topically, parenterally, and orally is improved by the use of microsponges drug delivery systems. Microsponges with particle sizes between 10 and 20 microns in diameter can entrap a wide range of different components and release them at predetermined rates. Additionally, microsponges provide regulated medication release at a specific place while also allowing the drug to circulate throughout the entire body. Microsponges effects might last up to 12 hours. Microsponges are reliant on the physiochemical characteristics of the medication. MDS has made by various method utilization emulsion system or by suspension polymerization between a liquid-liquid system. Microsponges can be used in formulations including creams, powders, gels, and lotions to entrap different types of drugs. The formulations of microsponge are stable from pH 1 to 11; 130°c. Therefore, the development of microsponge drug delivery systems has great potential and is a rapidly developing topic that will require further future research.
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